Effect of the internal fat of young Yakut horse on the radio resistance of laboratory mice under single X-ray impact
https://doi.org/10.31242/2618-9712-2019-24-3-12
Abstract
The antiradiation effect of the biological product from the internal fat of young Yakut horses on the resistance of white outbred male lab mice subjected to a single X-ray exposure dose of LD 100/30 was studied. It was established that a 30-day use of the biological product containing the fat of young Yakut horses and a 0.1 % stabilizing supplement of the Yagel dietary supplement after X-ray exposure contributes to 84 % survival of mice with full body weight, relative to biological control, restoration of the total number of leukocytes, neutrophils and lymphocytes in the peripheral blood of animals to the level of the physiological norm, and also normalizes the intensity of lipid peroxidation processes in hepatocytes. The effect is achieved due to the very high content of poly-unsaturated fatty acids, especially w-3 and w-6-polyunsaturated fatty acids.
Supporting agencies: This work was carried out within the framework of research plan «Development of biological products from tissues of plants and animals of Yakutia based on the study of the characteristics of their biochemical composition and mechanisms of adaptation to the conditions of the North» (no. state registration АААА-А17-117020110055-3. Project no. in FANO 0376-2016-0005), included in the FNI SO RAN program VI.62.1. «Fundamentals of biotechnology for development of therapies and disease diagnostics» on 2017–2020.
About the Authors
Boris Moiseevich Kershengolts
Institute for Biological Problems of Cryolithozone SB RAS
Russian Federation
Russian Federation
Kershengolts Boris Moiseevich, doctor of biological sciences, professor, principal researcher, Institute for Biological Problems of Cryolithozone SB RAS, 41 Lenina pr., Yakutsk, 677980, Russia,
https://orcid.org/0000-0001-8823-3981, kerschen@mail.ru;
Alla Nikolayevna Zhuravskaya
Institute for Biological Problems of Cryolithozone SB RAS
Russian Federation
Russian Federation
Zhuravskaya Alla Nikolayevna, doctor of biological sciences, principal researcher, Institute for Biological Problems of Cryolithozone SB RAS, 41 Lenina pr., Yakutsk, 677980, Russia,
https://orcid.org/0000-0002-7570-2328, jan43@mail.ru;
Leonid Nikolaevich Vladimirov
M.G. Safronov Yakut Scientific Research Institute of Agriculture
Russian Federation
Russian Federation
Vladimirov Leonid Nikolaevich, doctor of biological sciences, professor, acting director, M.G. Safronov Yakut Scientific Research Institute of Agriculture, Yakutsk,
677000, Russia.
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Review
For citations:
Kershengolts B.M., Zhuravskaya A.N., Vladimirov L.N. Effect of the internal fat of young Yakut horse on the radio resistance of laboratory mice under single X-ray impact. Arctic and Subarctic Natural Resources. 2019;24(3):134-144. (In Russ.) https://doi.org/10.31242/2618-9712-2019-24-3-12
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