National project of Russia “Bioeconomics” in the North-East of Eurasia: biopreparations from tissues of cold-adapted wild plants and native animal species

The North-East region of Eurasia offers substantial opportunities for advancing bioeconomy, primarily due to the unique array of bioactive substances present in the tissues of northern organisms. This phenomenon is significantly influenced by the region’s extreme natural and climatic conditions. The intact extraction of these bioactive substances, facilitated by contemporary physicochemical biotechnology, enables the development of biopreparations that possess regulatory and protective properties beneficial to human health. These biopreparations have extensive applications across various sectors, including medicine, the food industry, and cosmetology. Moreover, the utilization of secondary raw materials and waste generated by conventional northern economic activities –such as reindeer herding, the breeding of cold-adapted Yakut horses, hunting, fishing, and the cultivation and gathering of wild plants–has the potential to enhance profitability by 25 to 40%. This practice contributes to the improvement of quality of life, living standards, and health among the northern population. The Republic of Sakha (Yakutia) is endowed with the necessary conditions and components for the advancement of the biotechnology industry. This includes a unique array of bioactive substances, as well as self-renewable and environmentally sustainable northern plant and animal bio-raw materials. The region is characterized by a skilled workforce comprising biotechnologists and medical professionals who are actively engaged in the preclinical and clinical trials of developed biopreparations. An experimental bioworkshop at the Institute for Biological Problems of Cryolythozone SB RAS employs advanced physicochemical biotechnologies for the intact isolation of bioactive substance complexes derived from the tissues of cold-adapted wild plants and native animal species. The biopreparations produced in this bioworkshop have received certification from Rospotrebnadzor (EURASEC). This article provides a comprehensive overview of proprietary biopreparations, detailing their physicochemical properties, the results of preclinical and clinical trials, and their applications in preventive, therapeutic, and rehabilitative medicine. Furthermore, it addresses the significance of biopreparations in the manufacturing of functional food products by organizations and enterprises that are recognized as qualified entities, including medical institutions and entities within the food industry. The goals for the next stage of bioeconomy advancement in the region have been distinctly outlined.

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