Evaluation of biological activity and toxicity of wild plants extracts in Central Yakutia
https://doi.org/10.31242/2618-9712-2019-24-1-109-115
Abstract
Wild plants are a valuable bioactive factor to produce bioactive drugs. The initial assessment of biological products is the study of their biological activity and toxicity with respect to biological objects. A rapid assessment was made of the biological activity and toxicity of aqueous-alcoholic extracts obtained from six types of plant materials in Central Yakutia, using two methods of biotechnological processing. For the biological activity and toxicological properties of aqueous-alcoholic extracts obtained from several plant species in Central Yakutia, a test object is used the single-celled organism Paramecium caudate. Our data allowed us to identify some of the natural relationships between biological activity and toxicity at the cell level (for example, caudate paramecium), which are the initial target of the complex of biologically active substances contained in the extracts that have passed two studies. Further study of the effect of biologically active substances on cellular organisms. It has been established that there are some regular relationships between biological activity and toxicity at the cell level, which are the primary target of the action of the complex of biologically active substances required in the extracts obtained by the two products.
Keywords
Parametium caudatum,
biological activity,
toxicity,
hydroalcoholic extracts,
mechanochemical activation.
Supporting agencies: This article was made in the framework of SRW VI.62.1. «Development of biological products from the tissues of plants and animals of Yakutia on the basis of studying the characteristics of their biochemical composition and mechanisms of adaptation to the conditions of the North» (Reg. No. AAAA-A17-11702011005555-3).
About the Authors
M. U. Kan
Institute for Biological Problems of Cryolithozone SB RAS
Russian Federation
Russian Federation
KAN Mi Un, Candidate of Biological Sciences, Researcher, Institute for Biological Problems of Cryolithozone SB RAS, 41, pr. Lenina,Yakutsk, 677980, Russia, https://orcid.org/0000-0003-4339-4241, kanmiun@yandex.ru;
M. M. Shashurin
Institute for Biological Problems of Cryolithozone SB RAS
Russian Federation
Russian Federation
SHASHURIN Mikhail Mikhailovich, Candidate of Biological Sciences, Senior Researcher, Institute for Biological Problems of Cryolithozone SB RAS, 41, pr. Lenina,Yakutsk, 677980, Russia,
https://orcid.org/0000-0002-6785-1948, inwertaza@mail.ru;
A. N. Zhuravskaya
Institute for Biological Problems of Cryolithozone SB RAS
Russian Federation
Russian Federation
ZHURAVSKAYA Alla Nikolaevna, Doctor of Biological Sciences, Chief Researcher, Institute for Biological Problems of Cryolithozone SB RAS, 41, pr. Lenina,Yakutsk, 677980, Russia, https://orcid.org/0000-0002-7570-2328, jan43@mail.ru.
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Review
For citations:
Kan M.U., Shashurin M.M., Zhuravskaya A.N. Evaluation of biological activity and toxicity of wild plants extracts in Central Yakutia. Arctic and Subarctic Natural Resources. 2019;24(1):109-115. (In Russ.) https://doi.org/10.31242/2618-9712-2019-24-1-109-115
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